Sangjun Lee

Sangjun Lee

Speaker : Prof. Wojciech Chrzanowski

Date : 2011-05-16       

Title : Engineering Of Biointerface For Biomaterials And Drug Delivery Systems

Location : Room 114-01 Pharmacy Hall, Dankook University

Speaker : Prof. Wojciech Chrzanowski

Date : Date : 2011-05-18         

Title : Research Methods Particles Size Interactions And Topography.

Location : Room 108 Pharmacy Hall, Dankook University

Speaker : Prof. Wojciech Chrzanowski

Title : Particles Fabrication And Dip Pen Lithography For Drug Delivery

Date :: 2011-05-23

Location : Room 108 Pharmacy Hall, Dankook University

Speaker : Dr. Hany AboMosallem 

Title : Glass Ionomer Cement The Present And The Future Trends

Date : 2011-10-04

Location : Room 107Pharmacy Hall, Dankook University

Speaker : Jin Sung Choi (Assistant Professor, The Catholic University of Korea)

Date : 2011-12-13

Location : Room 108Pharmacy Hall, Dankook University

Abstract : Nav1.7 sodium channels can amplify weak stimuli in neurons and act as a threshold channel for firing action potentials. Neurotrophic factors and pro-nociceptive cytokines are released during development and under pathological conditions activate mitogen-activated protein kinases (MAPK). MAP kinases transduce the signal by regulating transcription factors thus initiating a gene expression response, a long-term effect, and directly modulate neuronal ion channels including sodium channels, thus acutely regulating DRG neuron excitability. For example, neurotrophic growth factor (NGF) activates (phosphorylates) ERK1/2 MAPK, PERK1/2, in DRG neurons, an effect which has been implicated in injury-induced hyperalgesia. However, the acute effects of PERK1/2 on sodium channels are not known. We have previously shown that activated p38 MAPK, pp38, directly phosphorylates Nav1.6 and Nav1.8 sodium channels and regulates their current densities without altering their gating properties. We now report that acute activation of ERK1/2 regulates resting membrane potential and firing properties of DRG neurons. We also show that PERK1/2 induces a hyperpolarizing shift of activation and fast-inactivation of Nav1.7 without altering current density, unlike the effect of pp38 on Nav1.6 and Nav1.8, and we demonstrate that this effect is mediated by the direct phosphorylation of specific residues within the first intracellular loop of the channel. Thus direct phosphorylation and modulation of Nav1.7 by PERK1/2 contribute to the effect of these kinases on DRG neuron excitability.

Speaker : Byung Gon Kim (Associate Professor, Ajou University School of Medicine) 

Date : 2011-12-14

Location : Room 108Pharmacy Hall, Dankook University

Abstract : Stem cell transplantation holds promise to promote anatomical repair and functional recovery after traumatic or ischemic injuries in CNS. Harnessing stem cells with therapeutic genes of interest is regarded as an attractive approach to augment therapeutic benefits of stem cell grafts. The advantage of stem cell-mediated gene transfer is the engraftibility of stem cells that can ensure a long-term and stable expression of therapeutic genes. In addition, stem cell-gene interaction may synergistically amplify therapeutic benefits. Delivery of classical neurotrophic factor genes provided neuroprotective and pro-regenerative effects in various injury models. Some studies employed therapeutic genes targeting post-injury microenvironment to support endogenous repair. Recent trials of stem cell-mediated transfer of nonclassical growth factors showed relatively novel biological effects. Combinatorial strategies seem to have the potential to improve therapeutic efficacy. Future development of induced pluripotent stem cells and novel scaffolding biomaterials will greatly expedite the advances of the ex vivo gene therapy to treat CNS injury. Before moving to the clinical stage, rigorous preclinical evaluation to identify an optimal gene or gene combination in different injury settings needs to be performed. Improving the safety of viral vectors will be a critical prerequisite for the clinical translation.

Speaker : Myung Soo Cho (책임연구원, 제일약품㈜ 중앙개발연구소 신약연구실) 

Date : 2011-12-20

Location : Room 108Pharmacy Hall, Dankook University

Abstract : 21세기에 들어 휴먼 제놈이 밝혀지면서 생물학에서는 genomics, proteomics등과 같은 생체 물질의 전체적인 변화를 보고자 하는 연구가 가능해졌으며 이러한 연구는 새로운 의약품 개발과 정확한 진단과 치료로 이어질 수 있는 의료기술의 혁신으로 이어지고 있습니다. 

바이오 의약품은 초창기 단백질 hormone이나 cytokine류로서 환자에게 부족한 단백질을 추가 하는 방향 이였지만 지금은 항체의약품과 같이 체내에서 악영향을 미치는 활성 성분을 억제하는 기능을 갖는 의약품의 시장이 크게 증가 되고 있으며 줄기세포 치료기술도 발전하고 있습니다. 그래서 바이오 의약품은 기존 의약품의 주류를 이루었던 정밀화학의약품을 대체하고 있는데 그 강점은 적은 부작용과 정확한 치료효과입니다. 이러한 강점은 맞춤형 의약품으로 발전해 나아가는데 이러한 진척에 선행되어야 하는 것이 해당 질병의 구체적인 원인이나 상태를 알려주는 바이오마커의 발굴입니다.     

본 세미나에는 프로테옴믹스를 이용한 바이오마커의 발굴과 그 기법들 그리고 이를 응용한 의약품개발을 함께 생각하고자 합니다

Speaker : Lim, Kook Jin, Ph.D. ㈜프로테옴텍 대표이사

Date : 2012-01-10

Location : Room 106Pharmacy Hall, Dankook University

Abstract : 21세기에 들어 휴먼 제놈이 밝혀지면서 생물학에서는 genomics, proteomics등과 같은 생체 물질의 전체적인 변화를 보고자 하는 연구가 가능해졌으며 이러한 연구는 새로운 의약품 개발과 정확한 진단과 치료로 이어질 수 있는 의료기술의 혁신으로 이어지고 있습니다. 

바이오 의약품은 초창기 단백질 hormone이나 cytokine류로서 환자에게 부족한 단백질을 추가 하는 방향 이였지만 지금은 항체의약품과 같이 체내에서 악영향을 미치는 활성 성분을 억제하는 기능을 갖는 의약품의 시장이 크게 증가 되고 있으며 줄기세포 치료기술도 발전하고 있습니다. 그래서 바이오 의약품은 기존 의약품의 주류를 이루었던 정밀화학의약품을 대체하고 있는데 그 강점은 적은 부작용과 정확한 치료효과입니다. 이러한 강점은 맞춤형 의약품으로 발전해 나아가는데 이러한 진척에 선행되어야 하는 것이 해당 질병의 구체적인 원인이나 상태를 알려주는 바이오마커의 발굴입니다.     

본 세미나에는 프로테옴믹스를 이용한 바이오마커의 발굴과 그 기법들 그리고 이를 응용한 의약품개발을 함께 생각하고자 합니다

Speaker : Hong, Kwan Soo (Principal Researcher, Korea Basic Science Institute) 

Date : 2012-01-17

Location : Room 103-01Pharmacy Hall, Dankook University

Abstract : Magnetic resonance imaging (MRI) is a widely used clinical diagnostic tool because it is non-invasive, provides contrast among soft tissues at high spatial resolution. Conventional MRI focuses almost exclusively on visualizing anatomy and has no specificity for any particular cell type. The 'probe' used in conventional MRI is the proton (1H) in mobile water molecules. New classes of exogenous MRI probes or reagents are needed to facilitate cell-specific imaging in living subjects. Elucidating the trafficking pathways of cells (immune and stem cells) in vivo, together with their migratory properties in relation to their differentiation and activation status, is useful for understanding how the immune system interacts with the related diseases. Methods based on tissue sampling to monitor immune responses are inadequate for repeatedly characterizing the responses of the immune system in different organs. A solution to this problem might come from molecular and cellular imaging - a branch of biomedical sciences that combines biotechnology and imaging methods to characterize, in vivo, the molecular and cellular processes involved in normal and pathologic states. The targeted cells are labeled with magnetic nano-particle-based multimodal contrast agents (CAs) in vivo or in vitro, which gives contrast where the labelled cells are. The CA-mediated in vivo molecular/cellular imaging provides new insights into the biology of cell trafficking and migration, in particular, the recruitment of immune cells into immune disease sites, and the longitudinal tracing of the transplanted cells homing to the disease sites.

Speaker : 박희곤 교수

Date : 2012-01-19

Location : Room 108Pharmacy Hall, Dankook University

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