Sangjun Lee

Sangjun Lee

Speaker : Dr.Oscar Castano

Date : 2010-07-29       

Title : Hybrid Materials As Ion Release Agents

Location : Rm 101  3rd Science Hall. Dankook University

Speaker : Prof. Ashraf F Ali

Date : 2010-08-28       

Title : Someproce Ssing Challenges In Synthesis Of Nanoceramic

Location : Rm 101  3rd Science Hall. Dankook University        

Sunday, 21 June 2015 09:59

17 - Phage In Use

Speaker : 남창훈

Date : 2010-11-22       

Title : Phage in use

Location : Room 107 3rd Science Hall. Dankook University

Speaker : 임재영

Date : 2011-04-13       

Title : Clinical Application For In-Vitro Muscle Function Study

Location : Room 106 Pharmacy Hall, Dankook University     

Speaker : 박정수 교수님

Date : 2011-04-13       

Title : Age-Related Changes In The Systemic Milieu Regulate Adult Neurogenesis

Location : Room 106 Pharmacy Hall, Dankook University     

Speaker : Prof. Wojciech Chrzanowski

Date : 2011-05-16       

Title : Engineering Of Biointerface For Biomaterials And Drug Delivery Systems

Location : Room 114-01 Pharmacy Hall, Dankook University

Speaker : Prof. Wojciech Chrzanowski

Date : Date : 2011-05-18         

Title : Research Methods Particles Size Interactions And Topography.

Location : Room 108 Pharmacy Hall, Dankook University

Speaker : Prof. Wojciech Chrzanowski

Title : Particles Fabrication And Dip Pen Lithography For Drug Delivery

Date :: 2011-05-23

Location : Room 108 Pharmacy Hall, Dankook University

Speaker : Dr. Hany AboMosallem 

Title : Glass Ionomer Cement The Present And The Future Trends

Date : 2011-10-04

Location : Room 107Pharmacy Hall, Dankook University

Speaker : Jin Sung Choi (Assistant Professor, The Catholic University of Korea)

Date : 2011-12-13

Location : Room 108Pharmacy Hall, Dankook University

Abstract : Nav1.7 sodium channels can amplify weak stimuli in neurons and act as a threshold channel for firing action potentials. Neurotrophic factors and pro-nociceptive cytokines are released during development and under pathological conditions activate mitogen-activated protein kinases (MAPK). MAP kinases transduce the signal by regulating transcription factors thus initiating a gene expression response, a long-term effect, and directly modulate neuronal ion channels including sodium channels, thus acutely regulating DRG neuron excitability. For example, neurotrophic growth factor (NGF) activates (phosphorylates) ERK1/2 MAPK, PERK1/2, in DRG neurons, an effect which has been implicated in injury-induced hyperalgesia. However, the acute effects of PERK1/2 on sodium channels are not known. We have previously shown that activated p38 MAPK, pp38, directly phosphorylates Nav1.6 and Nav1.8 sodium channels and regulates their current densities without altering their gating properties. We now report that acute activation of ERK1/2 regulates resting membrane potential and firing properties of DRG neurons. We also show that PERK1/2 induces a hyperpolarizing shift of activation and fast-inactivation of Nav1.7 without altering current density, unlike the effect of pp38 on Nav1.6 and Nav1.8, and we demonstrate that this effect is mediated by the direct phosphorylation of specific residues within the first intracellular loop of the channel. Thus direct phosphorylation and modulation of Nav1.7 by PERK1/2 contribute to the effect of these kinases on DRG neuron excitability.