Sangjun Lee

Sangjun Lee

Elsever 2015 Therapeutocally Relevant Aspects in Bone Repair and Regeneration

Over the past few years, attention has been focused on the therapeutic roles in designing bone scaffolds for successful repair and regeneration. Indeed, biologically dynamic events in the bone healing process involve many of the molecules and cells adherent to the scaffold. Recent bone scaffolds have been designed considering intrinsic chemical and physical factors and exogenous/extrinsic cues that induce bone regeneration. Here, we attempt to topically review the current trends and to suggest featured strategies for the design of therapeutically relevant bone scaffolds taking into account recent studies and applications.

Tissue-engineered scaffolds have played a decisive role in the repair and regeneration of a diverse range of tissues, including bone. These scaffolds not only provide a supporting matrix for cells especially in bone tissue engineering, but also provide essential environments for cells to spread, migrate, multiply, and conform to differentiation into specific lineage. For this, bone scaffolds should be tuned physico-chemically, to successfully repair and regenerate bone. Unlike conventional scaffolds that temporarily fill defects and need secondary surgery for their replacement and/or removal, promisingly therapeutic scaffolds have utilized a variety of biological actions that favor and trigger cells, especially stem cells, to carry out relevant therapeutic roles [1]. Bone repair or regeneration is a part of a complex dynamic event that involves many molecules and cells. After scaffold implantation, the therapeutic actions should thus be harmonized with the biological events and even facilitate a better healing process. Key events in the active healing process include mild inflammatory reactions with no tissue rejection, substantial angiogenesis to form blood vessels, recruitment of progenitor/stem cells, and driving these cells toward osteogenic lineage and finalizing matrix maturation. Therefore, tailoring the scaffolds to aid and stimulate these biological processes is an important milestone for scaffold-based bone engineering. In this topical review, we highlight designs of therapeutically relevant scaffolds that trigger cellular functions that benefit the repair and regeneration of bone, which will lead to the development of ideal scaffolds for bone engineering.

Dr. Eun-Jung Lee was granted NRF research fund for the year 2015.

Researchers Minsil & Jennifer Olmos visit Prof. Kam Leong’s lab at Columbia University in New York, USA.

Visit was for 3 months beginning from April, 2015. 

Friday, 26 June 2015 05:57

Prof. SC Kundu’s visit to ITREN

Professor SC Kundu will be visiting ITREN in Cheonan, Korea.

Speaker : 박주철 교수

Date : 2008-04-10       

Title : DSPP BSP 유전자의 발현을 조절하는 NFI-C TGF-β의 상호작용을 통한 상아질-수복상아질의 형성 기전

Location : Dental school bld., Dankook University

Speaker : 김은철 교수

Date : 2009-02-05       

Title : Biological Roles Of Dental Pulp Cells

Location : Rm Date : 201 3rd Science Hall. Dankook University

Speaker : 장준혁 교수

Date : 2009-03-11       

Title : Signal Transduction In Tissue Regeneration

Location : Rm Date : 203 3rd Science Hall. Dankook University

Speaker : Dr.Oscar Castano

Date : 2009-03-17       

Title : Inorganic Nanomaterials For Tissue Repair

Location : Rm Date : 201  3rd Science Hall. Dankook University