Prof. Kim HW granted NRF fund (300M won ~300,000$) per year up to 5 years for the research on immune- or angio-modulatory biomaterials.
A new type of cement (named 'nanocement') formulated with bioactive glass nanoparticles showed potential performance including angiogenic stimulation and osteoinductivity. The work was published in Biomaterials, 2018, 162, 183, by Kang MS et al.
A collaborative commercialization research institute, named GENTREN (GENoss + itREN) established with the supportive fund (500M/y up to 2 years) from NRF.
Gentren started to develop and commercialize dental synthetic bone graft materials and other root canal filling materials.
Our research and technologies initiated to become reality to the market throughout this project.
This was motivated by the transfer of two intellectural properties of Prof. Kim HW to biomaterials company (Genoss) with 100M won and 3% royalty
Bioactive multi-functional nanoparticles developed to treat and repair infected pulpal tissue through the delivery of silver ion and antibiotics. This work was published in Biomaterials, 2017, 142, 62 (Drug/ion co-delivery multi-functional nanocarrier to regenerate infected tissue defect).
Prof. Lee HH developed glass ionomer cement with improved mechanical properties and mineralization with the help of bioactive nanoparticles, highlighting the potential for dental caries treatment. This work was published in Dental Mater, 2017, 33(7), 805-817
Joint work led by Prof. Kim HW and Hyun JK reported the effective role of nanoceria optimally dosed to a contused spinal cord of rat in restoring the function. This work was published in Advanced Science, 2017, 8, 1700034, with the title ‘Functional Recovery of Contused Spinal Cord in Rat with the Injection of Optimal-Dosed Cerium Oxide Nanoparticles'.
A review article in Nano Today entitled ‘Extra- and intra-cellular fate of nanocarriers under dynamic interactions with biology’, provides insight into how the nanoparticles can journey along the biological barriers in extra and intracellular space with specific mechanisms, and how to design new nanoparticles for delivery purpose.
NRF grants successfully funded for:
Dr.Singh RK : Self-fluorescent and multi-imaging silica-based composite nanoparticles for cancer theranostics (2017-2020)
Dr.KimTH : Anti-inflammatory nanoparticles with drug and gene delivery capacity (2016-2019)
Dr.S Prakash Parthiban: Engineered fibrillar microenvironment to probe cell polarity under three dimensional conditions (2016-2019)
Microspheres developed to release silicate ions demonstrated excellent angiogenic effects in vitro and in vivo, suggesting the potential implication of silicate ions in stimulating angiogenesis. Moreover, the silicate ions synergize with VEGF, evidenced by the co-delivery approach. This research was published in Biomaterials, by Dashnyam K et al.
Speaker : Dr. Hyoung Woo Choi, ITREN
Location : Room 103 Pharmacy Building, Dankook University
Abstract: Inorganic biomaterial is one of the leading used materials for tissue regeneration, biosensing substrate, and drug delivery carrier and surface modification technique is a key factor to improve the inherent property. Among the various inorganic biomaterials, hydroxyapatite nano-crystal is very frequently used for bone tissue engineering and drug delivery system.
The use of hydroxyapatite nano-crystal not only plays a significant role in maintaining the mechanical properties of the natural bone but also offers a favorable environment for osteocoduction, protein adhesion, and osteoblast proliferation. In addition, the feature that an acidic environment induces the dissolution of hydroxyapatite nano-crystal into nontoxic ions has attracted researchers to the develop various pH-responsive drugs and gene delivery system.
Here I will introduce a novel approach to the fabrication of porous scaffolds with surface-immobilized nano-hydroxyapatite is developed for effective bone tissue engineering and light-responsive gatekeeper for smart nitric oxide delivery using hydroxyapatite and mesoporous silica nano-particle. The hydroxyapatite coating on mesoporous silica surface is expected to act as a shielding layer for the nitric oxide donors but is degraded by acids generated from chemical reagent, which induce exposure of the nitric oxide donors to the physical environment.