• a Department of Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, University College London, 256 Gray’s Inn Road, London WC1X 8LD, UK
    • b Department of Nanobiomedical Science & BK21 Plus NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan 330-715, Republic of Korea
    • c Institute of Tissue Regenerative Engineering (ITREN), Dankook University, Cheonan 330-715, Republic of Korea
    • d Department of Biomaterials Science, College of Dentistry, Dankook University, Cheonan 330-715, Republic of Korea

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Abstract

 

Sol–gel chemistry offers a flexible approach to obtaining a diverse range of materials. It allows differing chemistries to be achieved as well as offering the ability to produce a wide range of nano-/micro-structures. The paper commences with a generalized description of the various sol–gel methods available and how these chemistries control the bulk properties of the end products. Following this, a more detailed description of the biomedical areas where sol–gel materials have been explored and found to hold significant potential. One of the interesting fields that has been developed recently relates to hybrid materials that utilize sol–gel chemistry to achieve unusual composite properties. Another intriguing feature of sol–gels is the unusual morphologies that are achievable at the micro- and nano-scale. Subsequently the ability to control pore chemistry at a number of different length scales and geometries has proven to be a fruitful area of exploitation, that provides excellent bioactivity and attracts cellular responses as well as enables the entrapment of biologically active molecules and their controllable release for therapeutic action. The approaches of fine-tuning surface chemistry and the combination with other nanomaterials have also enabled targeting of specific cell and tissue types for drug delivery with imaging capacity.

 


 

Published in Publications

Professor Kim Hae WonHaewon Kim, Professor of Department of Nanobiomedical Science/College of Dentistry, in collaboration with Tissue Engineering laboratory researchers from University College Longon (UCL) has announced a new paper titled "Sol-Gel Based Materials for Biomedical Applications" January this year on "Progress in Materials Science".

해원 교수(대학원나노바이오의과학과/치과대학)가 이끄는 조직재생공학연구소 연구팀이 영국 유니버시티칼리지런던(UCL) 연구팀과 재료분야의 세계적인 초청 리뷰저널인 ‘Progress in Materials Science’ (IF=27) 에 ‘Sol-Gel Based Materials for Biomedical Applications’ 이라는 제목으로 올해 1월 논문을 발표했다.

김 교수는 조나단 놀스 교수와 함께 10여 년간 솔-젤 법에 의한 유무기 생체재료의 조직재생용 약물전달체 및 줄기세포 분화용 지지체 등을 개발하면서 우수한 연구논문을 발표해 관련 분야의 선구자적인 역량을 인정받고 있다. 조직재생공학연구소의 라젠드라싱 박사 또한 제1저자로서 연구에 큰 역할을 담당했다.

김 교수는 최근 3년간 ‘Materials Today’(IF=14), ‘Advanced Drug Delivery Reviews’(IF=15), ‘Advanced Functional Materials’(IF=11), ‘Cell Stem Cell’(IF=22), ‘ACS Nano’(IF=12.7) 등 임팩트가 높은 논문들을 7편이나 잇따라 발표하는 등 생체재료 및 재생의학 분야에서 세계 최고수준의 연구를 진행하고 있다. 그 동안 SCI급 연구논문 330여 편, 특허 120여 건과 함께 연구자의 세계적인 영향력을 평가하는 대표적 지표인 논문 피인용 횟수가 10,000회를 넘고, 논문의 질적 수준을 평가하는 주요지표인 h-index 값도 57을 기록 중이다.

김해원 교수는 고피인용 횟수 연구자에게 수여하는 상인 지식창조대상을 2010년에 수여한 바 있으며, 현재 조직재생공학연구소의 중점연구소사업과 BK21플러스 연구단, 그리고 최근 컬럼비아대학-UCL과 함께하는 글로벌연구실 사업을 이끌고 있다. 김 교수는 “조직재생공학연구소는 이미 세계적으로 톱 10% 정도의 연구그룹으로 인식되는 글로벌 브랜드를 지니고 있으며, 앞으로 톱 1%의 연구그룹이 될 수 있도록 구성원들과 최상위 연구에 계속 매진하겠다” 고 포부를 밝혔다. 

Original Post: Here

Published in Highlights

A postdoctoral position is currently available in the Institute of Tissue Regeneration Engineering (ITREN). ITREN, as a Priority Research Centre announced by Korea government, is a research institute established at Dankook University in 2007. Institute aims to advance interdisciplinary researches in regenerative medicine and tissue engineering, covering basic science to engineering and medicinal / dental applications. 

We are interested in developing nano-biomaterials and multi-faceted technological platforms for the in vitro and in vivo reprogramming of cells that have potential for regenerating damaged and diseased tissues, including musculo-skeletal and neuro-muscular systems. For this reason, we are seeking candidates who have experiences in biomaterials as well as strong expertise in the biological experiments and understating of cells and biology, with special focus in the following areas:

1) Reprogramming of somatic cells

2) Induced pluripotent stem cells and embryonic stem cells

3) Cellular biophysics or biomechanics (cell-material interactions)

4) Nanobiomaterials or drug/gene delivery systems (biopolymer or chemistry-based)


Candidates should have a PhD or equivalent degree in Biology, Biomedical Engineering, Tissue Engineering or related field. Excellent verbal and written communication skills are required. Candidates should be creative, independent, and dedicated to building a career in these fields. Salary will be commensurate with experience or capacity. We are seeking for immediate incorporation. To apply please send an email to This email address is being protected from spambots. You need JavaScript enabled to view it. with your 1) CV, 2) research interest and plan, and 3) the name of three contact references. For more information, please visit our website www.itren.kr.


Published in Positions
 
Elsever 2015 Therapeutocally Relevant Aspects in Bone Repair and Regeneration

Over the past few years, attention has been focused on the therapeutic roles in designing bone scaffolds for successful repair and regeneration. Indeed, biologically dynamic events in the bone healing process involve many of the molecules and cells adherent to the scaffold. Recent bone scaffolds have been designed considering intrinsic chemical and physical factors and exogenous/extrinsic cues that induce bone regeneration. Here, we attempt to topically review the current trends and to suggest featured strategies for the design of therapeutically relevant bone scaffolds taking into account recent studies and applications.

Introduction
Tissue-engineered scaffolds have played a decisive role in the repair and regeneration of a diverse range of tissues, including bone. These scaffolds not only provide a supporting matrix for cells especially in bone tissue engineering, but also provide essential environments for cells to spread, migrate, multiply, and conform to differentiation into specific lineage. For this, bone scaffolds should be tuned physico-chemically, to successfully repair and regenerate bone. Unlike conventional scaffolds that temporarily fill defects and need secondary surgery for their replacement and/or removal, promisingly therapeutic scaffolds have utilized a variety of biological actions that favor and trigger cells, especially stem cells, to carry out relevant therapeutic roles [1]. Bone repair or regeneration is a part of a complex dynamic event that involves many molecules and cells. After scaffold implantation, the therapeutic actions should thus be harmonized with the biological events and even facilitate a better healing process. Key events in the active healing process include mild inflammatory reactions with no tissue rejection, substantial angiogenesis to form blood vessels, recruitment of progenitor/stem cells, and driving these cells toward osteogenic lineage and finalizing matrix maturation. Therefore, tailoring the scaffolds to aid and stimulate these biological processes is an important milestone for scaffold-based bone engineering. In this topical review, we highlight designs of therapeutically relevant scaffolds that trigger cellular functions that benefit the repair and regeneration of bone, which will lead to the development of ideal scaffolds for bone engineering.

Published in Publications