Sunday, 06 November 2016 22:36

52 - Surface Modification of inorganic biomaterials for bioapplications : bone regeneration, biosensor and drug delivery system.

Written by
Rate this item
(0 votes)

Speaker : Dr. Hyoung Woo Choi, ITREN

Location : Room 103 Pharmacy Building, Dankook University

Date: 2016-10-31

Abstract: Inorganic biomaterial is one of the leading used materials for tissue regeneration, biosensing substrate, and drug delivery carrier and surface modification technique is a key factor to improve the inherent property. Among the various inorganic biomaterials, hydroxyapatite nano-crystal is very frequently used for bone tissue engineering and drug delivery system.

The use of hydroxyapatite nano-crystal not only plays a significant role in maintaining the mechanical properties of the natural bone but also offers a favorable environment for osteocoduction, protein adhesion, and osteoblast proliferation. In addition, the feature that an acidic environment induces the dissolution of hydroxyapatite nano-crystal into nontoxic ions has attracted researchers to the develop various pH-responsive drugs and gene delivery system.

 

Here I will introduce a novel approach to the fabrication of porous scaffolds with surface-immobilized nano-hydroxyapatite is developed for effective bone tissue engineering and light-responsive gatekeeper for smart nitric oxide delivery using hydroxyapatite and mesoporous silica nano-particle. The hydroxyapatite coating on mesoporous silica surface is expected to act as a shielding layer for the nitric oxide donors but is degraded by acids generated from chemical reagent, which induce exposure of the nitric oxide donors to the physical environment.

Read 884 times Last modified on Sunday, 06 November 2016 22:48

Leave a comment

Make sure you enter all the required information, indicated by an asterisk (*). HTML code is not allowed.

Latest Lectures