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Institute of Tissue Regeneration Engineering
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Medical Research Center
Medical Research Center
Institute of Tissue Regeneration Engineering
The Goal Mechanobiology
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Mechanobiology
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Mechanobiology Dental Medicine
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The Goal of Mechanobiology
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ABOUT US
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Biomaterials and Interfaces
Nanotherapeutics and Delivery
Stem Cell Engineering
Neural Regeneration
Musculoskeletal Tissue Engineering
Tooth Repair and Dental Materials
Degenerative Diseases
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BULLENTIN
Medical Research Center
The Goal Mechanobiology
Research Center
Mechanobiology
research field
Research ability of
Mechanobiology Dental Medicine
Core Faculty Members
The Goal of Mechanobiology
Research Center
MRC Lecture Series
Feature Articles
pH-gated antimicrobial hydrogel with conformational adaptation for precision therapeutic release
Kim YJ, Shin SJ, Lee YS, Yang YJ, Lee YJ, Jun SK, Lee HH, Kim HS, Shin US, Lee JH
Mechanobiological engineering strategies for oral and maxillofacial tissue regeneration
Park JH, Sagar V, Leong KW, Kim HW, Kim HS
Jammed Microfiber Inks Enable Aligned 3D Printing for Epigenetic Muscle Regeneration
Youn KI, Park JH, Mandakhbayar N, Taghizadeh M, Jin S, Kim J, Lee JH, Song KH
Launching Mechanobiology: A New Journal for the Science of Forces in Biology
Hae-Won Kim and Vivek Shenoy
Advances in Colloid and Interface Science (2026) Bioactive glasses in the new era: Technological advances and targeted therapies
Gupta A, Kurian AG, Jain SK, Singh RK, Kim HW
Biomaterials (2026) Regenerative dentistry with multifunctional nanomaterials: Orchestrating immunomodulatory, pro-angiogenic, stem cell activating, and antibacterial responses
Lee H, Lee JH, Kim HS, Lee HH, Kim HW
Advanced Science (2025) Temporal Stretch-Induced Nuclear Mechanosensing Coordinates Early Chromatin Accessibility and Genome Protection
Shim HW, Yoon JY, Lee HL, ... Lee JH*, Leong KW, Kim HW*
Bioactive Mater (2025) Bioprinting for drug screening: A path toward reducing animal testing or redefining preclinical research?
H Budharaju, RK Singh, HW Kim*
Trends in Biotechnology (2025), Biomechanics in miniature: microfluidic-based in vitro modeling to decipher mechanobiological phenomena
Hong HJ, Lee NH, Kim HS*, Leong KW, Kim HW*
Cell Reports (2025), Matrix-induced nuclear remodeling and mechano-therapeutics.
Lee JH, Yun YG, Kim HW*
Journal of Nanobiotechnology (2025) Advanced therapeutic scaffolds of biomimetic periosteum for functional bone regeneration
Gupta A, Kim KW, Kurian AG, Jain SK, Bhattacharya S, Singh RK*, Kim HW*
Bioactive Materials (2025) Mechanosignaling and 3D morphological adaptation of MSCs in response to hydrogel rigidity underpin angiogenic and immunomodulatory efficacy for ischemic injury regeneration
Yun YG , Heo SC , Jung JW , Yeo DH , Shin SJ , Tsogtbaatar K , Hwang YS , Lee JH * , Lee JH * , Kim HW *
ACS Nano (2025) Push-and-Pull Nanotherapeutics for Osteoarthritis with Drug Delivery and Dual Scavenging of Reactive Oxygen Species and Cell-Free DNA
Singh RK*, Mandakhbayar N, Kurian AG, Jain SK, Bhattacharya S, Gupta A, Lee JH, Kim HW*
Bioactive Materials (2025) Single-atom Pt-doped ceria nanozymes mitigate myocardial ischemia reperfusion injury via cardiomyocyte-targeted uptake and suppression of reactive oxygen species
Pu A , Sim WS, Ji YS, Kurian AG, Lee JH , Bui TVA, Lai Y, Hwangbo HS, Sun HH, Kim HW *, Park HJ *, Ban KW *
Materials Horizons (2025) Chondrocyte-mimetic therapeutic microcarriers for synergistic chemo-mechanical signaling in cartilage regeneration
Lee NH #, Zhou Z #, Yoon JY #, Mandakhbayar N, Li CJ, Lee JH, Kim HW *, Kim HS *
Advanced Functional Materials (2025) Eco-Fabricated Nanowave-Textured Implants Drive Microtubule-Assisted Nuclear Mechanotransduction and Chromatin Modification: Biophysical Priming for Osteogenesis and Bone Regeneration
Jeong B , Yoon JY, Ahn JY, Lee BH, Park SM, Kim JH,Bayarkhangai B, Kim YJ, Lee S, Knowles J C, Kim MY, Lee DJ, Rhee SH *, Lee HH *, Kim HW *, Lee JH*
Advanced Science (2025) Matrix-Rigidity Cooperates With Biochemical Cues in M2 Macrophage Activation Through Increased Nuclear Deformation and Chromatin Accessibility
Shin SJ ,Bayarkhangai B, Tsogtbaatar K, Meng YX, Kim SH, Kim YJ, Taghizadeh A, Kim DS, Kim DH, Lee JH *, Hyun JG *, Kim HW *
Biomaterials (2024) Electrically-stimulated cellular and tissue events are coordinated through ion channel-mediated calcium influx and chromatin modifications across the cytosol-nucleus space
Karunasagara S, Bayarkhangai B, Shim HW, Bae H J, Lee H, Taghizadeh A, Ji Y, Mandakhbayar N, Kim HS, Hyun J, Kim TJ, Lee JH*, Kim HW*
Bioactive Materials (2024) Adaptive immunity of materials: Implications for tissue healing and regeneration
JH Lee*, SJ Shin, JH Lee, JC. Knowles, HH Lee, HW Kim*
Advanced Science (2024) Neural Tissue-Like, not Supraphysiological, Electrical Conductivity Stimulates Neuronal Lineage Specification through Calcium Signaling and Epigenetic Modification
Li YM, Ji Y, Meng YX, Kim YJ, Lee H, Kurian AG, Park JH, Yoon JY, Knowles JC, Choi Y, Kim YS, Yoon BE, Singh RK, Lee HH, Kim HW*, Lee JH*
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2026 NRF Science and Engineering Research Support Program (Basic Research B)
Call for New Projects: 2026 Science and Engineering Research Support Program (Master’s Student Research Incentive Grant)
UCL Eastman-Korea Joint Center
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News & Story
Featured as Back Cover in Advanced Science
Temporal Stretch-Induced Nuclear Mechanosensing Cells subjected to temporal mild stretching rapidly activate their nuclear mechanosensing machinery, leading to changes in nuclear mechanics and epigenetic states that upregulate genes involved in genome protection and cellular plasticity. More details can be found in the Research Article by Jung-Hwan Lee, Kam W. Leong, Hae-Won Kim, and co-workers (DOI: 10.1002/advs.202510554).
2026-02-09
Featured as Back Cover in Advanced funct. Materials
Eco-Processed Nanowave-Textured Implants In their Research Article (10.1002/adfm.202503422), Sang-Hoon Rhee, Hae-Hyoung Lee, Hae-Won Kim, Jung-Hwan Lee, and co-workers report strong acid-free, eco-fabricated nanowave-textured implants that drive microtubule-assisted nuclear mechanotransduction for enhanced osteogenesis. The green-processed femtosecond laser-fabricated nanowave induces cellular and nuclear alignment along the wave axis and activates mechanosensitive pathways, leading to chromatin modifications that mediate stem cell priming for improved bone regeneration.
2025-10-23
Featured as Cover in ACS NANO
Push-and-Pull Nanotherapeutics for Osteoarthritis with Drug Delivery and Dual Scavenging of Reactive Oxygen Species and Cell-Free DNA In article, Singh and co-workers present a cationic-modified porous nanoceria as a multifunctional nanotherapeutic platform for the treatment of osteoarthritis. This “push-and-pull” strategy enables simultaneous delivery of an anti-inflammatory drug and scavenging of reactive oxygen species (ROS) and cell-free DNA (cfDNA). Their study demonstrates that this dual-action approach not only promotes chondrocyte regeneration but also reprograms macrophages toward an anti-inflammatory phenotype, ultimately contributing to cartilage repair in osteoarthritic joints. This important research is featured as the Cover in the August 2025 issue of ACS NANO.
2025-08-06
Featured as Frontispiece in Advanced Science
Matrix-Rigidity Cooperates With Biochemical Cues in M2 Macrophage Activation In article number 202570049, Shin and co-workers reveal how matrix rigidity interacts with biochemical signals to regulate M2 macrophage activation. Their study demonstrates that increased nuclear deformation and chromatin accessibility play a crucial role in this process, offering new insights into tissue regeneration and immunomodulation. This important research is featured as the Frontispiece in the August 2025 issue of Advanced Science.
2025-03-12
Featured as Back Cover in Advanced Science
Conductivity-Dependent Neuronal Specification In article number 2400586, Hae-Won Kim, Jung-Hwan Lee, and co-workers show that neural-tissue-like, low conductivity (0.02–0.1 S m–1) promotes neuronal differentiation via balanced calcium signaling and epigenetic changes, while supraphysiological, high conductivity (3.2 S m–1) causes apoptosis. This work reveals optimal conductivity's crucial role in neural interface design for tissue engineering and regenerative medicine.
2024-09-27
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2024-09-04
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2024-09-04
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2024-09-04
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Lecture Series
153. University of California, Timothy L. Downing, Biophysical Regulation of Cell Fate, from ECM to Nuclear Chromatin
152. Victer Chang Cardiac Research Institute, Charles D Cox, Mechanobiology and mechanical interaction of cells and tissues
151. Pennsylvania University, Dennis Discher, Mechanobiology and Immune Modulation in Cancer
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