Biomaterials (2021) Dual actions of osteoclastic-inhibition and osteogenic-stimulation through strontium-releasing...
Lee NH, Kang MS, ... Lee JH*, Kim HW*
Signal Trans Target Therapy (2021) Spatiotemporal control of CRISPR/Cas9 gene editing
Zhou C, Zhang J, Lee JH, ..., Kim HW*, Tao Y*, Li M*
Biomaterials (2021) Electricity auto-generating skin patch promotes wound healing process by activation of mechanosensitive ion...
Kim TH, Jeon WY, Ji Y, ... Lee JH*, Kim HW*
Science Adv. (2021) Scaffold-mediated CRISPR-Cas9 delivery system for acute myeloid leukemia therapy
Ho TC, Kim HS, ... Becker MW, Leong KW*
Biomaterials (2021) Therapeutic tissue regenerative nanohybrids self-assembled...
Kim HS, Lee JH, ... Shin US*, Kim HW*
J. Hepatology (2021) Dysregulation of the ESRP2-NF2-YAP/TAZ axis promotes hepatobiliary...
Hyun J, Al Abo M, ... Diehl AM*
Chem. Eng. J. (2021) Optimally dosed nanoceria attenuates osteoarthritic degeneration ...
Dashnyam K, Lee JH*, Singh RK,..., Kim HW*
Biomaterials (2021) Antibacterial, proangiogenic, and osteopromotive nanoglass...
Seo JJ, MAndakhbayar N, .., Lee JH, Kim HW*
Prog. Mater. Sci. (2020) Materials roles for promoting angiogenesis in tissue regeneration
Lee JJ, Parthiban P, Jin GZ, Knowles JC, Kim HW*
Biomaterials (2020) Protein-reactive nanofibrils decorated with cartilage-derived decellularized extracellular matrix for osteochondral defects
Kim HS, Mandakhbaya N, Kim HW, Leong K, Yoo HS*
Adv. Funct. Mater. (2020) Molecularly Imprinted Polymers and Electrospinning: Manufacturing Convergence ...
Patel K, Kim HW, Knowles JC, Poma A*
J. Clinical Investigation (2020) Epithelial splicing regulatory protein 2–mediated alternative splicing reprograms hepatocytes in severe alcoholic hepatitis
Jeongeun Hyun, ... Anna Mae Diehl*
Biomaterials (2020) - Revascularization and limb salvage following critical limb ischemia by nanoceria-induced Ref-1/APE1-dependent angiogenesis
Park IS, Mahapatra C, ... Lee JH*, Kim HW*
Biomaterials (2020) - Hierarchical microchanneled scaffolds modulate multiple tissue-regenerative processes of immune-responses, angiogenesis, and stem cell homing
Won JE, ..., Knowles JC, Kim HW*
Biomaterials (2019) - Anti-inflammatory action of folate-functionalized bioactive ion-releasing nanoparticle imply drug-free nanotherapy of inflamed tissue
Kim TH, Kang MS, ... Kim HW*
PNAS (2019) - Implantable multireservoir device with stimulus-responsive membrane for on-demand and pulsatile delivery of growth hormone
Lee SH, Piao H, Cho YC...... Choy JH*
Mater Horizons (2019) - Carbon based-nanomaterials as an emerging platform for theranostics
Patel KD, Singh RK, Kim HW*
Biomaterials (2019) - Role of nuclear mechanosensitivity in determining cellular responses to forces and biomaterials
Lee JH, Lee HH, Kim DH, Kim HW*
Adv Drug Deliv Rev (2019) - Advanced drug delivery systems and artificial skin grafts for skin wound healing
Kim HS, Sun X, Lee JH, Kim HW, Fu X, Leong KW*
Biomaterials (2018) - Nanocements produced from mesoporous bioactive glass nanoparticles.
Kang MS, Lee NH, Singh RK......... Lee JH, Kim HW*.
- (2020.10. People) Prof. Hae-Won Kim and Dr. Jung-Hwan Lee reviewed biomaterials roles for promoting angiogenesis in tissue regeneration.
Prof. Hae-Won Kim and Dr. Jung-Hwan Lee reviewed biomaterials roles for promoting angiogenesis in tissue regeneration. A review article entitled “Materials roles for promoting angiogenesis in tissue regeneration” has been published in Progress in Materials Science (IF 30.5).
(see the article: https://www.sciencedirect.com/science/article/pii/S0079642520300967).
In collaboration with Prof. Jonathan C. Knowles at UCL Eastman Dental Institute (UK) and Dr. Prakash Parthibana in ITREN, they reviewed recently highlighted therapeutic roles of biomaterials for accelerating angiogenesis in tissue regeneration.
Enabling angiogenesis is critical for the success of tissue repair therapies and the fate of tissue-engineered constructs.
Although many biochemical signaling molecules have been used, their biological functions in vivo are known to be limited, mainly due to their short lifetime and poor activity.
Matrices (or engineered biomaterials), beyond the biochemical signals, play pivotal roles in stimulating angiogenic processes with long-lasting efficacy with great angiogenic activity.
In this review, they discussed the proangiogenic effort taken to repair and regenerate various tissues including skin, bone, muscle and nerve, focusing on the roles of engineered matrices. This includes the design of pore structure and physico-chemical properties (nanotopology, stiffness, chemistry and degradability), the tailoring of matrices for proper presentation of growth factors and their crosstalks with adhesion ligands, the controlled and sustained delivery of angiogenic molecules and metallic ions, and the engineering of cells and construction of prevascularized tissues.
- (2020.07. People) Dr Hye Sung Kim significantly improved a repair of osteochondral defects using a cartilage-mimicking scaffold
- Dr. Hye Sung Kim significantly improved a repair of osteochondral defects using a cartilage-mimicking scaffold
Dr. Hye Sung Kim at ITREN significantly improved a repair of osteochondral defects using a cartilage-mimicking scaffold. A research article entitled “Protein-reactive nanofibrils decorated with cartilage-derived decellularized extracellular matrix for osteochondral defects” has been published in Biomaterials (IF 10.273)
(see the article: https://www.sciencedirect.com/science/article/pii/S0142961220304609).
In collaboration with Prof. Kam W. Leong at Columbia University (USA) and Prof. Hyuk Sang Yoo at Kangwon National University (South Korea), she has developed a cartilage-mimicking scaffold based on an electrospun nanofiber-based 3-D scaffolds, named “nanofibril”. Cartilage is an avascular tissue and thus it barely regenerates once is damaged. So far stem cell therapy is the best hope but the clinical application is limited due to the poor cell survival in the body. To overcome this issue, her team provided stem cells a cartilage-specific microenvironment in 3-D using nanofibril. The surface of the scaffold was decorated with bovine cartilage-derived decellularized extracellular matrix (dECM) which replicates compositional and structural features of the cartilage tissue. The significance of this study is that the amount of dECM chemically immobilized on the scaffolds is largely improved via a robust surface modification method called surface-initiated atom transfer radical polymerization (SI-ATRP). The cartilage-dECM decorated nanofibril not only improved the cell adhesion and proliferation, but also stimulated the chondrogenic differentiation of adipose-derived mesenchymal stem cells, leading to an improved repair of osteochondral defects.
She said “I’m thrilled to report this exciting results in such an impactful journal in biomedical field. I could not do it without the collaborator’s help. I would really love to continue active collaboration with global institutes here at ITREN”
(See her interview with BRIC: https://www.ibric.org/myboard/read.php?Board=tr_interview&id=211527&qinterview=Y).
- (2020.06. People) Dr. Kapil D. Patel published a review paper in Advanced Functional Material (IF: 16.836).
- Dr. Kapil D. Patel published review paper titled “Molecularly Imprinted Polymers and Electrospinning: Manufacturing Convergence for Next‐Level Applications” in Advanced Functional materials (2020) in collaboration with Eastman Dental Institute, University College London, UK
Micro- and especially nanofiber-type materials are extremely attractive for a number of applications, ranging from separation and analysis to drug delivery, wound healing and tissue engineering, and the majority of them are currently produced worldwide via the extremely popular and effective electrospinning technique.
The addition of specific tailored molecular recognition capability to these electrospun materials via the established molecular imprinting technology can be extremely beneficial for a number of applications, as indicated by the number of examples in the literature over the past 15 years. However, the integration of these two technologies has proven to be quite challenging, mainly due to the different processing methodologies which characterize the two approaches. In this progress report, the practical difficulties related to the combination of electrospinning and molecular imprinting (MIPs) and to the production of molecularly-imprinted electrospun fibers are addressed. We discuss the main aspects to take into consideration when designing and optimizing the experimental protocols, as well as highlight the most prolific research applications that have been explored thus far. We conclude with a commercial/industrial and economic perspective on the envisaged market for these hybrid products. Currently, we are working to explore the combination of the two technologies for biomedical/tissue engineering applications.
- (2020.05. People) ITREN faculty members are granted funds from Korea National Research Foundation
- We are thrilled to announce our five ITREN faculties have been selected as recipients of research grant funded by Korea National Research Foundation. The heroes and heroines are Jun-Hee Lee, Goeun Choi, Jeongeun Hyun, Hye Sung Kim, Rajendra Kumar Singh, and Huyian Piao. Congratulations to all of them!
- (2020.05. People) Dr. Jeongeun Hyun identified a novel mechanism of liver failure in severe alcoholic hepatitis patients
- Dr. Jeongeun Hyun at ITREN identified a novel molecular cell biological mechanism whereby liver failure (a condition in which liver function is extremely deteriorated) occurs in human and animals with alcoholic hepatitis. The research article (Title: Epithelial splicing regulatory protein 2-mediated alternative splicing reprograms hepatocytes in severe alcoholic hepatitis) has been published in a world prominent academic journal, Journal of Clinical Investigation (IF=12.282). (https://www.jci.org/articles/view/132691)
Severe alcoholic hepatitis is a deadly liver disease without an effective medical therapy. Although mortality of severe alcoholic hepatitis is known to correlate with hepatic accumulation of immature liver cells, underlying mechanism is poorly understood. Dr. Hyun and her research team demonstrated that expression of ESRP2 (epithelial splicing regulatory protein-2) was suppressed in hepatocytes of both severe alcoholic hepatitis patients and various mouse models of alcoholic hepatitis. ESRP2 is an RNA splicing factor that maintains the mature phenotype of adult hepatocytes. Loss of ESRP2 permitted re-emergence of fetal RNA isoforms that allowed hepatocyte reprogramming to immature hepatocytes that are less functional. She also showed in animal experiments that depleting ESRP2 in mice exacerbated alcohol-induced steatohepatitis.
Dr. Hyun said, “as it has identified important regulators and the mechanism of alcoholic hepatitis progression, it will be of great help in future research for prevention and treatment of alcoholic hepatitis”.
Based on her previous findings, Jeongeun Hyun, who came to Dankook University in March 2020, is actively conducting research to apply advanced nano-bio convergence technology and apply it to the clinic for the treatment of liver disease and liver regeneration.
The ITREN plans to pioneer new research fields, such as new nanotherapies and in vitro culture models, to apply our knowledge accumulated from researches on nerve, muscle, bone, teeth, cartilage, and vascular regeneration to the liver regeneration.