Matrix-Rigidity Cooperates With Biochemical Cues in M2 Macrophage Activation

In article number 202570049, Shin and co-workers reveal how matrix rigidity interacts with biochemical signals to regulate M2 macrophage activation. Their study demonstrates that increased nuclear deformation and chromatin accessibility play a crucial role in this process, offering new insights into tissue regeneration and immunomodulation.

This important research is featured as the Frontispiece in the August 2025 issue of Advanced Science.