In Vivo Animal Models:

We develop animal models to test our hypothesis and to examine in vivo phenomena of the developed biomaterials, manipulated cells and tissue-engineered constructs. Most studies are in rodent (rat and nude mouse) and some are in rabbit, beagle dog, and porcine, targeting diseases and damaged tissues in neuro-musculo-skeletal systems.

Below are details developed thus far in ITREN, and more are under development.

• Bone models: calvarium critical-sized defect, alveolar bone critical-sized defect, vertical bone augmentation, bone fracture model for large bone defects
• Cartilage defect model for hydrogel-cell
• Tendon repair models: patellar tendon, Achilles tendon
• Bone-cartilage model for hydrogel implant
• Bone-ligament model
• Periodontal ligament defect model
• Tooth extraction model
• Dentin regeneration model
• Skeletal muscle defect models
• Aorta blood vessel model for tissue engineered BV
• Spinal cord injury model for neural regeneration
• Sciatic nerve model for nerve conduits
• Temporomandibular joint model for osteoarthritis disease treatment
• Osteoporosis model (ovariectomy) for bone disease treatment
• Ischemic injury model in hind limb