Core Faculty Members

Jeong-Eun Hyun

Assistant Professor Jeong-Eun Hyun Core Faculty
Institute of Tissue Regeneration Enginnering (ITREN)

Jeongeun Hyun received her Ph.D. degree in Integrated Biological Science from Pusan National University in 2016.

She studied the role of microRNAs in transdifferentiation of hepatic stellate cells and therapeutic effect of microRNAs in liver fibrosis during Ph.D. course.

Following her graduation, she worked in Pusan National University as a postdoctoral researcher and a lecturer in Cell Biology. In 2017, she joined the Dr. Diehl’s laboratory at Duke University as a postdoctoral associate and studied the role of RNA-binding proteins in the control of cellular plasticity during adult liver regeneration and in clinically relevant liver diseases that have defects in regulating cell fate.

Dr. Hyun is currently an assistant professor at Institute of Tissue Regeneration Engineering (ITREN) since 2020.

Her primary research focuses are mechanobiological mechanisms underlying hepatic pathogenesis, 2) nanotherapies in liver diseases, and liver/multi-organ organoid.


  • Molecular Cell Biology, Hepatology


  • Bachelor Degree: From Pusan National University (2006.3-2010.8)
  • Masters Degree: From Pusan National Univ. (2011.3-2013.2)
  • Ph.D: From Pusan National Univ. (2013.3-2016.2)


  • (2016.3-2016.8) - Lecturer in Cell Biology, Pusan National University, Republic of Korea
  • (2016-2017) - Postdoc., BK21 Plus Research Group Longevity and Marine Biotechnology, Pusan National University, Republic of Korea
  • (2017-2020) - Postdoc., Division of Gastroenterology, Department of Medicine, Duke University, USA
  • (2020~current) - Assistant Professor, Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Republic of Korea

Selected Papers

  • [22] Epithelial splicing regulatory protein 2-mediated alternative splicing reprograms hepatocytes in severe alcoholic hepatitis. J Clin Invest. (2020)
  • [21] Single-Cell RNA Sequencing Identifies Yes-Associated Protein 1-Dependent Hepatic Mesothelial Progenitors in Fibrolamellar Carcinoma. Am J Pathol. (2020)
  • [20] Increased Glutaminolysis Marks Active Scarring in Nonalcoholic Steatohepatitis Progression. Cell Mol Gastroenterol Hepatol. (2019)
  • [19] Dysregulated Activation of Fetal Liver Program in Acute Liver Failure. Gut. (2019)
  • [18] RNA Binding Proteins Control Transdifferentiation of Hepatic Stellate Cells into Myofibroblasts. Cell Physiol Biochem. (2018)
  • [17] MicroRNA-378 is involved in hedgehog-driven epithelial-to-mesenchymal transition in hepatocytes of regenerating liver. Cell Death Dis. (2018)
  • [16] Hedgehog-YAP Signaling Pathway Regulates Glutaminolysis to Control Activation of Hepatic Stellate Cells. Gastroenterology. (2018)
  • [15] Tumor necrosis factor-inducible gene 6 protein ameliorates chronic liver damage by promoting autophagy formation in mice. Exp Mol Med. (2017)
  • [14] Thymosin beta-4 regulates activation of hepatic stellate cells via hedgehog signaling. Sci Rep. (2017)
  • [13] Hedgehog Signaling is Associated with Liver Response to Fractionated Irradiation in Mice. Cell Physiol Biochem. (2016)
  • [12] MicroRNAs in liver fibrosis: Focusing on the interaction with hedgehog signaling. World J Gastroenterol. (2016)
  • [11] Kombucha tea prevents obese mice from developing hepatic steatosis and liver damage. Food Sci Biotechnol. (2016)
  • [10] MicroRNA expression profiling in CCl4-inducedliverfibrosisofMus musculus. Int J Mol Sci. (2016)
  • [9] MicroRNA-378 limits activation of hepatic stellate cells and liver fibrosis by suppressing Gli3 expression. Nat Commun. (2016)
  • [8] MicroRNA125b-mediated Hedgehog signaling influences liver regeneration by chorionic plate-derived mesenchymal stem cells. Sci Rep. (2015)
  • [7] Tumor necrosis factor-inducible gene 6 promotes liver regeneration in mice with acute liver injury. Stem Cell Res Ther. (2015)
  • [6] Hepatic stellate cells express thymosin Beta 4 in chronically damaged liver. PLoS One. (2015)
  • [5] Potential role of Hedgehog signaling and microRNA-29 in liver fibrosis of IKKβ-deficient mouse. J Mol Histol. (2014)
  • [4] Hedgehog signaling influences gender-specific response of liver to radiation in mice. Hepatol Int. (2013)
  • [3] Potential role of Hedgehog pathway in liver response to radiation. PLoS One. (2013)
  • [2] Hedgehog signaling regulates the repair response in mouse liver damaged by irradiation. Radiat Res. (2013)
  • [1] Potential roles of hedgehog and estrogen in regulating the progression of fatty liver disease. J Life Sci. (Korean) (2011)

Selected Papers (Google Scholar) LINK